| Time | Saturday on TV | Channel |
| Auto Racing |
| Noon | Indianapolis 500 pole qualifying | ESPN |
| 1 p.m. | Indianapolis 500 pole qualifying | ABC |
| 5 p.m. | Indianapolis 500 pole qualifying | ESPN |
| 7:30 p.m. | Nextel Cup: Chevy American Revolution 400 | FX |
| 8 p.m. | NHRA: Southern Nationals qualifying (same-day tape) | ESPN |
| Boxing |
| 3:30 p.m. | Calvin Brock vs. Serguei Lyakhovich | NBC |
| Golf |
| 9 a.m. | EPGA: Asian Open | GOLF |
| 2 p.m. | LPGA: Franklin American Mortgage Championship | ESPN2 |
| 3 p.m. | PGA: Byron Nelson Championship | CBS |
| Horse Racing |
| Noon | Woodlawn & Hirsch Jacobs Stakes | ESPN2 |
| 2 p.m. | Gallorette Handicap, Maryland Breeders' Cup Handicap, Sir Barton Stakes & Argent Dixie Stakes | ESPN |
| 5 p.m. | Preakness Stakes | NBC |
| Major League Baseball |
| 7 p.m. | Atlanta at Milwaukee | TBS |
| 10 p.m. | Chicago Cubs at San Diego | WGN |
| 10 p.m. | Cincinnati at Los Angeles | FSN |
| Motorsports |
| 4 p.m. | AMA Superbike | SPEED |
| NBA Playoffs |
| 8 p.m. | Miami at Indiana | TNT |
| 10:30 p.m. | San Antonio at L.A. Lakers | TNT |
| NHL Playoffs |
| 3 p.m. | Tampa Bay at Philadelphia | ABC |
| MLS Soccer |
| 4 p.m. | New England at Columbus | ESPN2 |
| Time | Saturday on Radio | Channel |
| Horse Racing |
| 5 p.m. | Preakness Stakes | WCKY-AM (1360) |
| Major League Baseball |
| 10 p.m. | Cincinnati at Los Angeles | WLW-AM (700) |
| Time | Sunday on TV | Channel |
| Auto Racing |
| 1 p.m. | Indianapolis 500 time trials | ESPN2 |
| 2 p.m. | Craftsman: UAW/GM Ohio 250 | SPEED |
| 6 p.m. | Indianapolis 500 time trials | ESPN2 |
| 7 p.m. | NHRA: Southern Nationals (same-day tape) | ESPN2 |
| 9:30 p.m. | FIA World Rally: Cyprus Rally (same-day tape) | SPEED |
| Arena Football |
| 3 p.m. | Colorado at Indiana | NBC |
| Golf |
| 9 a.m. | EPGA: Asian Open (same-day tape) | GOLF |
| 3 p.m. | PGA: Byron Nelson Championship | CBS |
| 4 p.m. | LPGA: Franklin American Mortgage Championship | ESPN2 |
| Major League Baseball |
| 2 p.m. | Atlanta at Milwaukee | TBS |
| 3 p.m. | Minnesota at Chicago White Sox | WGN |
| 4 p.m. | Cincinnati at Los Angeles | FSN |
| 8 p.m. | Anaheim at Baltimore | ESPN |
| Motorsports |
| Noon | MotoGP World Championship (same-day tape) | SPEED |
| 1 p.m. | MotoGP 250 (same-day tape) | SPEED |
| 4:30 p.m. | AMA Superbike | SPEED |
| 5:30 p.m. | FIM World Superbike
(same-day tape) | SPEED |
| NBA Playoffs |
| 3:30 p.m. | Minnesota at Sacramento | ABC |
| 8 p.m. | Detroit at New Jersey | TNT |
| NHL Playoffs |
| 4 p.m. | San Jose at Calgary | ESPN |
| Time | Sunday on Radio | Channel |
| Major League Baseball |
| 4 p.m. | Cincinnati at Los Angeles | WLW-AM (700) |
