| Date | Opponent | Time |
| Sept. 4 | Cincinnati (ESPN Regional): Mark Dantonio returns to OSU. | Noon |
| Sept. 11 | Marshall (ABC): The Herd return QBs Stan Hill and Graham Gochneaur, WR Josh Davis and RB Earl Charles (1,039 rushing yards). | 3:30 p.m. |
| Sept. 18 | at North Carolina State (ABC): Last year the Buckeyes won in triple OT. | 3:30 p.m. |
| Oct. 2 | at Northwestern (ESPN/ESPN2): The Wildcats haven't beaten OSU since 1971. | 7:45 |
| Oct. 9 | Wisconsin: The Badgers were one of just two teams that beat OSU last season (17-10). | TBA |
| Oct. 16 | at Iowa: Hawkeyes return seven starters on D, including DE Matt Roth and LB Abdul Hodge. | TBA |
| Oct. 23 | Indiana: The Hoosiers are trying to improve on last year's 2-10 finish. | TBA |
| Oct. 30 | Penn State: Joe-Pa's still trying to get over last year's nine-loss season. | TBA |
| Nov. 6 | at Michigan State: Some uncertainty - QB and RB spots were still open in the preseason. | TBA |
| Nov. 13 | at Purdue: QB Kyle Orton was named Big Ten Preseason Offensive Player of the Year. | TBA |
| Nov. 20 | Michigan (ABC): Could decide who wins the Big Ten title for the second straight year. | 1 p.m. |
