| Date | Opponent | Time |
| Sept. 5 | at Louisville (ESPN): Despite coach Rich Brooks' efforts, the Cardinals are up first.
| 3:30 p.m. |
| Sept. 18 | Indiana: UK has won eight of the last nine. | 7 p.m. |
| Sept. 25 | at Florida: Now led by QB Chris Leak, Gators have won 17 straight meetings with UK. | TBA |
| Oct. 2 | Ohio: OU is looking to recover from a loaded MAC schedule last year that left the Bobcats with a 2-10 record. | 7 p.m. |
| Oct. 9 | Alabama: Coach Mike Shula will try to improve on his inaugural 4-9 year with the Tide, who are still on probation. | 7 p.m. |
| Oct. 16 | South Carolina: After 5-7 season, Lou Holtz took away the offensive coordinator position from his son Skip - and gave it to himself.
| 7 p.m. |
| Oct. 23 | at Auburn: QB Jason Campbell (2,267 passing yards) and RB Carnell Williams (1,307 rushing yards) both return. | TBA |
| Oct. 30 | at Mississippi State: New head coach Sylvester Croom, the first black coach in the Southeastern Conference. | TBA |
| Nov. 6 | Georgia: One of nation's best again led by the Davids - QB David Greene on offense and DE David Pollack on defense. | 1 p.m. |
| Nov. 13 | Vanderbilt: The Commodores went 2-10 last year - and beat UK. | 1 p.m. |
| Nov. 27 | at Tennessee: Only nine starters return to the Vols, who have won 19 straight meetings with the Wildcats. | TBA |
